does semaglutide cause dry mouth Semaglutide-associated hyposalivation: A report of case series Does Ozempic Cause Mouth Sores?

Key Points The incretins glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are gut-derived hormones that potentiate insulin secretion and contribute to glucose metabolism through a wide range of physiological actions Inhibitors of the incretin-inactivating enzyme dipeptidyl peptidase 4 (DPP-4) and DPP-4-resistant injectable GLP-1 receptor agonists have been developed for the treatment of hyperglycaemia in type 2 diabetes mellitus (T2DM) GLP-1 and other gut-derived hormones might directly and/or indirectly regulate electrolyte and fluid homeostasis by influencing feeding and drinking behaviour as well as electrolyte transport in the kidneys and gastrointestinal tract GLP-1 receptor (GLP-1R) agonists and DPP-4 inhibitors increase natriuresis in T2DM, possibly through overlapping and distinct mechanisms, and might slightly improve renal haemodynamics in the setting of diabetes-related glomerular hyperfiltration Incretin-based therapies seem to directly influence renal physiology and have indirect metabolic and haemodynamic actions that might reduce renal risk in T2DM

Lixisenatide In the ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) study, T2D patients with a recent coronary artery event were randomly assigned (1:1) to a lixisenatide (1020 g) group or placebo group (Pfeffer et al., 2015)

Warning signs of dangerous dehydration include dark urine, dizziness when standing, inability to keep down fluids for more than 12 hours, decreased urination, extreme fatigue, confusion, or rapid heartbeat

Keep protein high (1-1.2g per pound) during cuts